Authorship note: bkm and mee contributed equally to this work and are co-first authors. conflict of interest: mlw has received research support and consulting fees from bristol-myers squibb and celdara medical and has served on advisory boards for acceleron and boehringer ingelheim. mlw is a scientific founder of celdara medical. dk has received consulting fees from astrazeneca, boehringer ingelheim, csl behring, and genentech/roche as well as research support on behalf of the university of michigan from bayer, bristol-myers squibb, and pfizer. dk owns stock options in eicos sciences inc. jeg has received research grants from abbvie, anaptysbio, janssen, pfizer, novartis, celgene/bristol-myers squibb, and eli lilly and has served on advisory boards for novartis, abbvie, eli lilly, miragen, and almirall. cs is a statistical consultant for fifth eye inc. she is a member of a data monitoring committee for studies that pay an honorarium for astellas pharma and endo pharmaceuticals