Autocrine netrin function inhibits glioma cell motility and promotes focal adhesion formation

HIGHLIGHTS

  • who: Andrew A. Jarjouru00a4 et al. from the Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada have published the research work: Autocrine Netrin Function Inhibits Glioma Cell Motility and Promotes Focal Adhesion Formation, in the Journal: (JOURNAL) of September/28,/2011
  • what: Using transfilter migration assays the authors demonstrate DCC-dependent chemoattractant migration of U87 cells up a gradient of netrin-1. To netrins` well-characterized chemotropic activity the authors demonstrate an autocrine function for netrin-1 and netrin-3 in U87 and U373 cells that slows migration. The authors . . .

     

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