HIGHLIGHTS
- who: Domiziana Costamagna and colleagues from the Department of Clinical and Biological Sciences, University of Torino, Torino, Italy have published the research: Autologous iPSC-Derived Human Neuromuscular Junction to Model the Pathophysiology of Hereditary Spastic Paraplegia, in the Journal: Cells 2022, 11, x FOR PEER REVIEW of /2022/
- what: The aim of this study was to develop a stem_cell-based NMJ model to investigate pathological mechanisms and evaluate their therapeutic potential in HSP patients. In the current study, diseased HSP-derived lower MNs also showed prominent axonal swelling, highlighting the tendency of these HSP-lower . . .
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