Autolysosomal activation combined with lysosomal destabilization efficiently targets myeloid leukemia cells for cell death

HIGHLIGHTS

• who: Harshit Shah from the Hunan Normal University, China have published the paper: Autolysosomal activation combined with lysosomal destabilization efficiently targets myeloid leukemia cells for cell death, in the Journal: (JOURNAL)
• what: In the present study, using Multiple myeloid leukemia (ML) cell lines and primary ML cells, the authors demonstrate that the combination of mefloquine and mTOR inhibition exceeded by far the reported anticancer effect of a single treatment without any detectable increase in the toxicity to human CD34+ hematopoietic cells. Fusion rescues mefloquine plus mTOR inhibition-induced LCD Pharmacologic inhibition presents several important limitations . . .
  

   

  

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