Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors

HIGHLIGHTS

• who: Joe R. Delaney et al. from the for Neurodegeneration and Neurotherapeutics, Duke University School of Medicine, Durham, North Carolina have published the Article: Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors, in the Journal: (JOURNAL) of January/10,/2020
• what: The authors focused on two shRNAs whose impact was neither complete nor minimal, but as close to a 50% target PLOS Genetics | https://doi.org/10.1371/journal.pgen .
• how: To investigate the effects of BECN1 haploinsufficiency in ovarian cancer the authors developed a pseudo-haploinsufficiency knockdown . . .
  

   

  

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