Autophagy impairment in liver cd11c+ cells promotes non-alcoholic fatty liver disease through production of il-23

HIGHLIGHTS

• who: Lauriane Galle-Treger from the Keck School University of have published the paper: Autophagy impairment in liver CD11c+ cells promotes non-alcoholic fatty liver disease through production of IL-23, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: Utilizing a neutralizing antibody against IL-2318,19, the authors demonstrate that preventative inhibition of IL-23 not only protects against the development of glucose intolerance and insulin insensitivity, but could also dampen the development of NAFLD. Histological analysis was conducted to evaluate steatosis, ballooning, lobular inflammation, and NAS of control and Atg5 CD11cKO mice (Fig . . .
  

   

  

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