HIGHLIGHTS
- who: Christian Pangilinan from the Street, Philadelphia, PA, USA University of Pennsylvania, Philadelphia, PA, USA have published the Article: Autophagy Paradox: Strategizing Treatment Modality in Melanoma, in the Journal: (JOURNAL)
- what: Although further analyses are certainly needed to understand the mechanisms of autophagy attenuation in these resistant tumors, this study provided the clinical evidence to the importance of the autophagy pathway in modulating anti-tumor T_cell immunity.
SUMMARY
Interestingly, using in_vitro functional assays and syngeneic animal models, Yamamoto and co-workers studied pancreatic ductal adenocarcinoma (PDAC) expressing a dominant-negative mutant . . .
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