Autophagy regulates hepatocyte identity and epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions promoting snail degradation

HIGHLIGHTS

  • who: G Grassi from the National InstituteSapienza University of Medical and Dental Sciences, Chuo-ku, Niigata, Japan have published the research work: Autophagy regulates hepatocyte identity and epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions promoting Snail degradation, in the Journal: (JOURNAL)
  • what: The authors investigated the functional relationship between autophagy and hepatocyte differentiation with a particular focus on EMT/MET dynamics. The authors report that lack of autophagy leads to a decreased expression of epithelial markers with the concomitant induction of the mesenchymal programme.
  • how: The authors analysed whether p62 interacts with . . .

     

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