Avoiding collider bias in mendelian randomization when performing stratified analyses

HIGHLIGHTS

SUMMARY

Mendelian randomization (MR) is the use of genetic variants as instrumental variables to assess the causal relationship between a risk factor and an outcome. Any variable that is a causal descendent of collider is also affected by the same variables and so is itself a collider; hence in MR any variable influenced by the risk factor is a collider (Fig 1B). If risk of developing the disease is influenced by the risk factor, then it is a collider when considering disease progression as the outcome, and selection of the study sample would result in . . .

 



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