Azacitidine is synergistically lethal with xpo1 inhibitor selinexor in acute myeloid leukemia by targeting xpo1/eif4e/c-myc signaling

HIGHLIGHTS

  • who: Huideng Long and collaborators from the Department of Hematology, Zhongda Hospital, School of Medicine, Southeast University, Institute of Hematology Southeast University, Nanjing, China have published the research work: Azacitidine Is Synergistically Lethal with XPO1 Inhibitor Selinexor in Acute Myeloid Leukemia by Targeting XPO1/eIF4E/c-MYC Signaling, in the Journal: (JOURNAL) of 30/01/2022
  • what: The authors explore the antitumor effect of KPT-330 combined with AZA in AML through CCK-8 flow cytometry RT-qPCR western blot and RNA-seq the results showed that KPT-330 combined with AZA synergistically reduced cell . . .

     

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