HIGHLIGHTS
- who: Alberto Bueno-Costa from the Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain have published the research: B-cell leukemia transdifferentiation to macrophage involves reconfiguration of DNA methylation for long-range regulation, in the Journal: (JOURNAL) of 18/Oct/2019
- what: The authors report that transdifferentiation events in the context of hematopoietic lineage plasticity, such as the pre-B-ALL lineage conversion to macrophage studied herein, involve DNA methylation shifts that not only affect CpG sites in lineal proximity to genes, but also incur epigenetic changes in long-range interactor sequences derived . . .
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