HIGHLIGHTS
- who: Younseo Oh from the Biological, PA, USA have published the research work: B7-H3 regulates osteoclast differentiation via type I interferon-dependent IDO induction, in the Journal: (JOURNAL) of 12/05/2021
- what: The authors aimed to elucidate the function of B7-H3 and establish B7-H3 as a regulatory mechanism in osteoclast differentiation in RA. The authors focused the investigations on the effect of IFN-β since previous studies showed that IFN-β, and not IFN-α, inhibits RANKL-induced osteoclastogenesis. The authors show that unlike in PBMCs, B7-H3 knockdown does not result in osteoclastogenesis . . .
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