Back from the dead: the atypical kinase activity of a pseudokinase regulator of cation fluxes during inducible immunity

HIGHLIGHTS

• who: Elizabeth K. Brauer and Sorina C. Popescu from the Ghent, Belgium of Würzburg, Germany have published the paper: Back From the Dead: The Atypical Kinase Activity of a Pseudokinase Regulator of Cation Fluxes During Inducible Immunity, in the Journal: (JOURNAL)
• what: In line with its unusual metal ion cofactor-binding domain, the authors demonstrate that ILK1 phosphorylates a broader range of peptides in the presence of Mn2+ compared to Mg2+ but that it primarily phosphorylates serine and threonine residues. Both Mn2+ and Mg2+ (5 mM) were included during ILK1 incubation on the arrays . . .
  

   

  

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