Bacterial growth and ceftriaxone activity in individual ascitic uids in an model of spontaneous bacterial peritonitis

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SUMMARY

    In this study, bacterial growth and ceftriaxone activity were evaluated in individual AF using an in_vitro model of SBP, reflecting the environment and pharmacokinetics at the infection site. Studies have found altered antibiotic activity when substituting standardized growth media for body fluids, such as urine (Erdogan-Yildirim et_al, 2011; Yang et_al, 2014), bile (Rees and Elliott, 1998; Wulkersdorfer et_al, 2017), cerebrospinal fluid (Matzneller et_al, 2016), peritoneal fluid (König et_al, 1998; Miglioli et_al, 1998) or, indeed, AF (Miglioli et_al, 2005). Using the model, the authors assessed bacterial growth and the activity of ceftriaxone, a . . .

     

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