Bacterial nonhomologous end joining ligases preferentially seal breaks with a 3⠲-oh monoribonucleotide*

HIGHLIGHTS

• who: Hui Zhu from the (UNIVERSITY) have published the Article: Bacterial Nonhomologous End Joining Ligases Preferentially Seal Breaks with a 3⠲-OH Monoribonucleotide*, in the Journal: (JOURNAL) of March/28,/2008
• what: The authors report that nick sealing by LigD and LigC enzymes is stimulated by the presence of a single ribonucleotide at the broken 3ⴕ-OH end.

SUMMARY

Direct evidence that bacteria catalyze DNA double-strand break (DSB)2 repair via nonhomologous end joining (NHEJ) emerged from studies of the repair of linear plasmid DNAs transfected into mycobacteria. Unlike homologous . . .

 



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