HIGHLIGHTS
- who: Ioannis Kienes from the University of North Carolina at Chapel Hill, United States have published the Article: Bacterial subversion of NLR-mediated immune responses, in the Journal: (JOURNAL)
- what: The authors focus on well-studied members of the NLR-family, a class of host PRRs that are expressed in the cytosol. In this study, it was demonstrated that some NOD2 variants with mutations in the LRR domain, responsible for detection of PGN , were unable to bind vimentin which correlated with the inability of NOD2 to localise to the plasma_membrane and initiate the cellular degradation . . .
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