Bad-lamp controls tlr9 trafficking and signalling in human plasmacytoid dendritic cells

HIGHLIGHTS

• who: Alexis Combes from the CNRS UMR5286, LYON , FranceSciences Program University of have published the article: BAD-LAMP controls TLR9 trafficking and signalling in human plasmacytoid dendritic cells, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors show using human primary pDCs and the BPDCNderived CAL-1 cell line that BAD-LAMP controls the sorting of TLR9 in different endosome subsets and favors pro-inflammatory cytokine production.
• how: As BAD-LAMP levels correlated with the dysfunctional status of TA-pDCs the authors examined the consequences of treating pDCs in_vitro with tumours supernatants . . .
  

   

  

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