HIGHLIGHTS
- who: BAF and colleagues from the University of Michigan Medical Center, Ann Arbor, Michigan, USA have published the paper: BAF60c formation through epigenetic control of vascular smooth muscle cell homeostasis, in the Journal: (JOURNAL)
- what: The authors show that loss of BAF60c aggravates AAA, indicating a protective role of BAF60c-dependent chromatin remodeling in AAA through preservation of the VSMC contractile phenotype and inhibition of VSMC inflammation and apoptosis. Through systematic analysis of the contributions of BAF60c to AAA pathology and VSMC biology, the authors provide mechanistic insights into the epigenetic regulation of AAA. The . . .
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