HIGHLIGHTS
- What: In this model, the authors introduced a diet intervention on obese mice and examined the effects of BAFF neutralization on IR . The authors show that obese C57BL/6J mice, but not the lean mice produce IgG autoAbs that bind to apoptotic adipocytes. This study provides the first evidence that IgG autoAbs generated during high-fat diet-induced obesity bind to dead adipocytes and promote their phagocytic clearance.
- Who: . and collaborators from the University of Pennsylvania, United States have published the Article: BAFF neutralization impairs the autoantibody-mediated clearance of dead adipocytes and aggravates obesity . . .
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