Bag3 alleviates atherosclerosis by inhibiting endothelial-to-mesenchymal transition via autophagy activation

HIGHLIGHTS

  • who: Hongtao Diao and collaborators from the Guangdong TCM Key Laboratory for Metabolic Diseases, Guangdong Pharmaceutical University, Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Guangzhou, China have published the Article: BAG3 Alleviates Atherosclerosis by Inhibiting Endothelial-to-Mesenchymal Transition via Autophagy Activation, in the Journal: Genes 2022, 13, 1338. of /2022/
  • what: The authors aim investigate the role of in atherosclerosis and elucidate the potential molecular mechanism. This study identified the correlation between EndMT and autophagy and clarified that BAG3 could regulate autophagy-induced EndMT by constituting the CASA complex.
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