HIGHLIGHTS
- who: Ruijia Yang from the Shanxi Key Lab of Bone and Soft Tissue Injury Repair, Department of Orthopaedics, The Second Hospital of Shanxi Medical University, Taiyuan, China have published the article: Bardoxolone methyl ameliorates osteoarthritis by inhibiting osteoclastogenesis and protecting the extracellular matrix against degradation, in the Journal: (JOURNAL)
- what: The study showed that CDDO-Me inhibited the phosphorylation and nuclear translocation of p65, and osteoclast fusion and resorption genes, including CTSK, Integrinu03b23 and DC-STAMP are under the transcriptional_control of NFATc1 and were subsequently reduced by CDDO-Me, eventually, osteoclast formation was significantly inhibited . . .
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