HIGHLIGHTS
- who: Manickaraj M. from the InstitutUniversity of Zurich, Zurich, Switzerland have published the article: BASIC RESEARCH, in the Journal: (JOURNAL)
- what: HNF1B is necessary to directly reprogram fibroblasts to induced renal tubule epithelial_cells (iRECs) and, as the authors demonstrate, can induce ectopic pronephric tissue in Xenopus ectodermal organoids. The authors explore conserved transcriptional programs in renal tubulogenesis and congenital renal malformations by comparative analysis in Xenopus and directly reprogrammed mammalian cells. The authors focused on 13 factors with a strong expression during renal organogenesis (Emx2, Esrrb, Foxc1, Gata3, Hnf1a, Hnf1b, Hnf4a, Lhx1, Pax8, Pou3f3, Sall1 . . .
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