Bdnf/trkb axis provokes emt progression to induce cell aggressiveness via crosstalk with cancer-associated fibroblasts in human parotid gland cancer

HIGHLIGHTS

• who: Kazumasa Moriwaki from the DepartmentPharmaceutical University have published the article: BDNF/TRKB axis provokes EMT progression to induce cell aggressiveness via crosstalk with cancer-associated fibroblasts in human parotid gland cancer, in the Journal: Scientific Reports Scientific Reports
• what: The authors investigated the involvement of the BDNF/TRKB pathway in PGC. Using primary co-culture systems and immunohistochemical and clinicopathological analyses of human samples from patients with PGC, the authors demonstrate that upregulation of the BDNF/TRKB pathway in PGC cells regulates PGC cell aggressiveness via crosstalk with CAFs. As the BDNF/TRKB pathway . . .
  

   

  

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