Behavioral and inflammatory sex differences revealed by celecoxib nanotherapeutic treatment of peripheral neuroinflammation

HIGHLIGHTS

• who: Brooke Deal from the DepartmentDuquesne University have published the research work: Behavioral and inflammatory sex differences revealed by celecoxib nanotherapeutic treatment of peripheral neuroinflammation, in the Journal: Scientific Reports Scientific Reports
• what: The authors demonstrate that under the same surgical conditions of nerve injury (CCI), male and female rats exhibit transitions to quantitatively equivalent hypersensitivity. The authors demonstrate for the first time that in females, a single low-dose injection of CXB-NE can reduce neuroinflammation and mechanical hypersensitivity. The authors show that when hypersensitivity returns, CXB-NE treated sciatic nerves exhibit to a . . .
  

   

  

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