Benzoquinone, a leukemogenic metabolite of benzene, catalytically inhibits the protein tyrosine phosphatase ptpn2 and alters stat1 signaling

HIGHLIGHTS

• who: Romain Duval from the (UNIVERSITY) have published the article: Benzoquinone, a leukemogenic metabolite of benzene, catalytically inhibits the protein tyrosine phosphatase PTPN2 and alters STAT1 signaling, in the Journal: (JOURNAL) of March/29,/2019
• what: The authors show here that 1,4benzoquinone directly impairs PTPN2 activity. The authors show that 1,4-benzoquinone, the prime hematotoxic metabolite of benzene, is an irreversible inhibitor of PTPN2. The authors provide mechanistic and kinetic evidence that the inhibition of PTPN2 by 1,4-benzoquinone occurs through the irreversible formation of a covalent adduct of 1,4-benzoquinone . . .
  

   

  

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