Berberine stimulates lysosomal ampk independent of pen2 and maintains cellular ampk activity through inhibiting the dephosphorylation regulator uhrf1

HIGHLIGHTS

• who: AMPK and collaborators from the Yantai University, China have published the Article: Berberine stimulates lysosomal AMPK independent of PEN2 and maintains cellular AMPK activity through inhibiting the dephosphorylation regulator UHRF1, in the Journal: (JOURNAL)
• what: The authors focused on AXIN1, which played an essential role in co-translocating LKB1 onto the v-ATPase-Ragulator complex for lysosomal AMPK activation (Zhang et_al, 2016). The authors focused on the protein degradation process of UHRF1. The present study, for the first time, showed that BBR and metformin possessed different mechanisms on AMPK activation.
• how: The . . .
  

   

  

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