Bevacizumab suppressed degenerative changes in articular cartilage explants from patients with osteoarthritis of the knee

HIGHLIGHTS

• who: Masaichi Sotozawa from the Cartilage tissues of the lateral femoral condyle were obtained from eight patients (age , u00b1, ., years) with OA (Kellgren-Lawrence grade, ) of the medial compartment who underwent total knee arthroplasty, with informed consent and approval of the institutional review board at Yokohama City University (#B191100008). After subchondral bone was trimmed out, cylindrical, fulldepth, articular cartilage explants were harvested using an osteochondral harvester with an internal diameter of, ., mm (Smith and Nephew Inc [, ]. Andover, MA, USA), and they were cultured in serum-free media for , h. Cartilage explants were then cultured in Dulbecco`s . . .
  

   

  

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