HIGHLIGHTS
- who: Sanne Venneker et al. from the Department of Pathology, Leiden University Medical Center, ZA Leiden, The Netherlands have published the research work: Beyond the Influence of IDH Mutations: Exploring Epigenetic Vulnerabilities in Chondrosarcoma, in the Journal: (JOURNAL)
- what: The authors explored whether the methylome is altered upon progression from IDH mutant enchondroma towards chondrosarcoma. Alterations in the methylome of IDH mutant cartilage tumors are associated with tumor progression and this study shows that targeting of epigenetic regulators could be a potential therapeutic strategy for both IDH wildtype and IDH mutant chondrosarcoma patients.
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