HIGHLIGHTS
- who: Astrid S. Ju00f8rgensen from the Faculty University of Copenhagen, Copenhagen, Denmark have published the paper: Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization, in the Journal: (JOURNAL) of 11/Oct/2020
- what: On this background the authors investigate the constitutive and liganddependent CXCR4 internalization pattern as well as CXCR4mediated u03b2-arrestin recruitment and show that plerixafor in contrast to AMD11070 is biased with intrinsic u03b2-arrestin recruitment agonism and full G protein antagonism. The authors compare the in vivo cell mobilization properties of the two . . .
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