Biased il-2 signals induce foxp3-rich pulmonary lymphoid structures and facilitate long-term lung allograft acceptance in mice

HIGHLIGHTS

• who: Yoshito Yamada from the Mice, month-old female C BL/ J mice, mice expressing diphtheria toxin (DT) receptor under the Foxp, promoter (Foxp DTR have published the research work: Biased IL-2 signals induce Foxp3-rich pulmonary lymphoid structures and facilitate long-term lung allograft acceptance in mice, in the Journal: (JOURNAL) of 14/07/2020
• what: Collectively, the authors report that short-term, high-intensity and biased IL-2 pre-conditioning facilitates acceptance of vascularized and ventilated lung allografts without the need of immunosuppression, by inducing Foxp3-controlled iTLS formation within allografts. This . . .
  

   

  

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