Biased signaling and allosteric modulation at the fshr

HIGHLIGHTS

  • who: Eric Reiter from the CNRS, IFCE, Université Tours, Nouzilly, France University of Modena and Reggio have published the research: Biased Signaling and Allosteric Modulation at the FSHR, in the Journal: (JOURNAL)
  • what: Strikingly, this study demonstrated that blocking FSH action using antibodies against FSHβ protects ovariectomized mice against bone loss, by stimulating new bone formation and reducing bone removal besides inhibiting fat accumulation.
  • future: That the FSHR could signal in endocytic compartments through G proteins in a similar way as the PTHR but from VEE is conceivable but further studies are needed . . .

     

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