Bile acid-drug interaction via organic anion-transporting polypeptide 4c1 is a potential mechanism of altered pharmacokinetics of renally excreted drugs

HIGHLIGHTS

• who: Minami Yamauchi and colleagues from the Faculty of Pharmaceutical Sciences, Tohoku University, Sendai, Japan have published the article: Bile Acid-Drug Interaction via Organic Anion-Transporting Polypeptide 4C1 Is a Potential Mechanism of Altered Pharmacokinetics of Renally Excreted Drugs, in the Journal: (JOURNAL)
• what: The aim of the study is to assess the effect of bile acids on OATP4C1-mediated transport to clarify the mechanisms underlying the altered dynamics of renally excreted drugs in patients with liver failure.
• how: Meanwhile the BDI indices obtained in the study were the maximum values while . . .
  

   

  

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