Bile duct ligation-induced cirrhosis does not alter the blood-brain barrier permeability to sucrose in rats

HIGHLIGHTS

• What: The authors used brain uptake clearance of_[13C]sucrose, which uses both the brain concentrations and blood or plasma exposure of the marker, to investigate the time course of the effects of cholestatic liver disease on BBB permeability to low MW compounds in BDL rats. The authors selected a time course of five days to 4 weeks for the studies because the studies reporting an elevated BBB permeability were carried out between five days (Quinn et_al 2014) and four weeks (Dhanda and Sandhir 2017) after BDL surgery in rats. The studies reported here (Fig 4b and . . .
  

   

  

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