Bin1 recovers tauopathy-induced long-term memory deficits in mice and interacts with tau through thr348 phosphorylation

HIGHLIGHTS

• who: Maxime Sartori from the (UNIVERSITY) have published the Article: BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation, in the Journal: (JOURNAL)
• what: The authors developed a multidisciplinary approach encompassing molecular, cellular, and behavioral experiments to determine how BIN1 is involved in the pathophysiological processes of AD.
• how: The authors developed a high-content screening approach to characterize modulators of the BIN1-Tau interaction in an agnostic way (1 compounds targeting multiple pathways) and the authors identified-among others-an inhibitor of calcineurin a . . .
  

   

  

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