Binary-fret reveals transient excited-state structure associated with activity-dependent camkii – nr2b binding and adaptation

HIGHLIGHTS

• who: Tuan A. Nguyen from the (UNIVERSITY) have published the Article: Binary-FRET reveals transient excited-state structure associated with activity-dependent CaMKII - NR2B binding and adaptation, in the Journal: (JOURNAL) of 16/03/2022
• what: The authors show that a transient excited-state intermediate exists where paired catalytic-domains in the holoenzyme first separate prior to subsequent NR2B association. The authors show that the fluorescent emission of a single FP can be used to monitor two FRET signals. This experiment demonstrates that calciumcalmodulin binding is required for catalytic-domain separation and subsequent NR2B binding . . .
  

   

  

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