HIGHLIGHTS
- who: Kyle V. Marra and colleagues from the DepartmentUniversity of, La Jolla, California, USA have published the research: Bioactive extracellular vesicles from subset of endothelial progenitor cells rescue retinal ischemia and neurodegeneration, in the Journal: (JOURNAL)
- what: The authors report that bioactive extracellular vesicles from CD44hi ECFCs (EVshi) are paracrine mediators recapitulating the effects of intact cell therapy in murine models of ischemic/neurodegenerative retinopathy; vesicles from ECFCs with low expression levels of CD44 (EVslo) were ineffective. This study exploited these findings to identify trophic miRs in shed EVs from bioactive CD44hi ECFCs (EVshi).
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