HIGHLIGHTS
- who: Mikyung Kim from the (UNIVERSITY) have published the paper: Biochemical and Functional Analysis of Smallpox Growth Factor (SPGF) and Anti-SPGF Monoclonal Antibodies*, in the Journal: (JOURNAL) of January/13,/2004
- what: The authors show that after recombinant expression, refolding, and purification, the EGF domain of SPGF binds exclusively to the broadly expressed cellular receptor, erb-B1 (EGF receptor), with subnanomolar affinity, stimulating the growth of primary human keratinocytes and fibroblasts. Because the SPGF is thought to derive from the EEV membrane and EEV particles are the numerically minor fraction of viruses in the . . .
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