Biodegradable polymeric nanocapsules prevent cardiotoxicity of anti-trypanosomal lychnopholide

HIGHLIGHTS

• who: Renata Tupinambá Branquinho from the (UNIVERSITY) have published the article: Biodegradable Polymeric Nanocapsules Prevent Cardiotoxicity of Anti-Trypanosomal Lychnopholide, in the Journal: (JOURNAL) of 28/03/2017
• what: The authors show that repeated-dose administration of free LYC can potentially promote severe cardiotoxicity in mice, as evidenced by alterations of both global heart function and intracellular Ca2+ handling, with a critical effect on the RyR2 channel.
• how: Altogether the results showed that both under basal conditions and during Iso-induced stress the repeated-dose administration of LYC modifies contractility Ca2+ handling and . . .
  

   

  

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