HIGHLIGHTS
- who: Carlotta Granchi from the DepartmentUniversity of have published the paper: Biological Activity of Natural and Synthetic Compounds, in the Journal: Molecules 2022, 27, 3652. of 24/05/2022
SUMMARY
The natural compound lesbicoumestan, isolated from the flowering plant Lespedeza bicolor, showed a promising antileukemia potential by inducing the degradation of mucosaassociated lymphoid tissue lymphoma translocation protein 1 (MALT1), thus leading to the inhibition of the NF-κB signalling pathway, a well-known negative regulatory factor of apoptosis. Lesbicoumestan showed apoptotic effects on human leukemia cells by several mechanisms: it increased mitochondrial reactive . . .
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