Biological aging of cns-resident cells alters the clinical course and immunopathology of autoimmune demyelinating disease

HIGHLIGHTS

• who: Jeffrey R. Atkinson and colleagues from the DepartmentState University Wexner Medical Center, Columbus, Ohio, USA have published the paper: Biological aging of CNS-resident cells alters the clinical course and immunopathology of autoimmune demyelinating disease, in the Journal: (JOURNAL) of June/22,/2022
• what: The authors show that experimental autoimmune encephalomyelitis (EAE) induced by the adoptive transfer of encephalitogenic CD4+ Th17 cells was more severe and less likely to remit in middle-aged compared with young adult mice.
• how: For the middle-aged cohort the authors used mice 40-44 weeks of . . .
  

   

  

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