HIGHLIGHTS
SUMMARY
Exclusion criteria were as follows: all studies published before 2000, pre-clinical studies on experimental models, prenatal and post-mortem studies, studies not assessing CUD, and studies not assessing relapse or closely related outcomes. Biomarker of: % severity of CUD: and amp; leptin plasmatic levels N=40 Cross-sectional Escobar et_al, 2018 % withdrawal symptoms: % plasmatic adipokine levels N=104 Cross-sectional Levandowski et_al, 2013 and amp; abstinence: % prolactin plasmatic levels N=86 Prospective Patkar et_al, 2002 and amp;: decreased, %: increased. In Patkar et_al, 2002 study, higher prolactin levels were observed in CUD compared with healthy . . .
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