HIGHLIGHTS
- who: Benke Hong from the (UNIVERSITY) have published the research: Biosynthesis of strychnine, in the Journal: (JOURNAL) of 21/07/2022
- what: The authors report the biosynthetic pathway of strychnine, along with the related molecules brucine and diaboline. The authors report the discovery of nine enzymes that convert geissoschizine 1 to diaboline 8, strychnine 10 and brucine 11, using a combination of chemical logic, -omics datasets and enzymatic characterization.
- how: Source data are provided with this paper.
SUMMARY
The authors successfully recapitulate strychnine, brucine and diaboline biosynthesis in Nicotiana . . .
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