Biphenyl ether analogs containing pomalidomide as small-molecule inhibitors of the programmed cell death-1/programmed cell death-ligand 1 interaction

HIGHLIGHTS

• who: Shabnam Shaabani and colleagues from the Department of Drug Design, University of Groningen, AV Groningen, The Netherlands have published the research work: Biphenyl Ether Analogs Containing Pomalidomide as Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction, in the Journal: Molecules 2022, 27, x FOR PEER REVIEW of /2022/
• what: Using an ex vivo PD-1/PD-L1 blockade cell line bioassay that expresses human PD-1 and PD-L1 the authors show that compounds 4 and 5 significantly restore the repressed immunity in this co-culture model . . .
  

   

  

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