Bladder cancer organoids as a functional system to model different disease stages and therapy response

HIGHLIGHTS

• who: Martina Minoli from the Establishment and culture of BLCa PDOs from diverse clinical samples PDOs were generated from specimens obtained from patients that underwent either TUR-B, cystectomy, or nephroureterectomy (Fig1a, Tables, Supplementary Data, ) at the Inselspital, University Hospital in Bern and representing the spectrum of BLCa, ranging from lowgrade (LG) non-invasive to high-grade (HG) invasive tumors, including both NMIBC and MIBC. PDOs were derived and grown in suspension, from fresh and cryopreserved tissue and cryopreserved single cells. PDO cultures were successfully established from BLCa samples irrespective of tumor stage, grade or histological pattern . . .
  

   

  

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