Blocking autophagy with chloroquine aggravates lipid accumulation and reduces intracellular energy synthesis in hepatocellular carcinoma cells, both contributing to its anti-proliferative effect

HIGHLIGHTS

• who: Fengming Xu from the Department of General, Visceral and Vascular Surgery, Jena University Hospital, Jena, Germany have published the Article: Blocking autophagy with chloroquine aggravates lipid accumulation and reduces intracellular energy synthesis in hepatocellular carcinoma cells, both contributing to its anti-proliferative effect, in the Journal: (JOURNAL)
• what: The study showed that treating HepG2 cells with the autophagy inhibitor chloroquine led to intracellular lipid accumulation suggesting an impairment of lipid degradation.
• how: The immunohistochemical results showed that CQ down-regulated Ki-67 protein expression in HepG2 cells compared to controls while HGF . . .
  

   

  

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