HIGHLIGHTS
- who: Erwin De Genst from the Centre Oslo University have published the article: Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors report a rapid, robust and efficient pipeline for the development of intrabody based IVEB, by a combination of simple in_vitro selection of a synthetic VHH phage-display library for intrabody discovery and the use of small modRNA libraries for rapid intracellular and in_vivo validation, followed by the in_vivo delivery of intrabodies using AAV vectors for validation of physiological effects. For . . .
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