HIGHLIGHTS
SUMMARY
Bloom Syndrome (BSyn, OMIM #210900) is a rare monogenic autosomal recessive disorder with symptoms ranging from below average height and weight and lesions on exposed skin areas, to reduced fertility and shortened life expectancy most often brought on by heightened proneness to cancer development. The defective gene (BLM; ) responsible for the condition was mapped to 15q26.1 in the human genome and encodes a 3′-5′ DNA helicase showing homology to the E. coli RecQ protein. To create a novel model for BSyn, the authors generated a null allele for blm and analysed its . . .
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