HIGHLIGHTS
- who: Sample and colleagues from the , Blvd Niels Bohr, Villeurbanne, France have published the Article: BMC Systems Biology, in the Journal: (JOURNAL)
- what: The authors focus on repression-based transcriptional regulation loops composed of three genes, i.e. repressilators. The authors show that when parameters related to the spatial organization of the genes change, the repressilator undergoes a sharp transition between the oscillatory and stationary regime. Their computational cost still forbids to use them for thorough exploration of the parameter space with reasonable statistical significance, which is precisely the objective of the present work. In . . .
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