Bmx controls 3βhsd1 and sex steroid biosynthesis in cancer

HIGHLIGHTS

• who: Xiuxiu Li and colleagues from the Center for Therapeutics Cleveland Clinic, Cleveland, Ohio, USA have published the paper: BMX controls 3u03b2HSD1 and sex steroid biosynthesis in cancer, in the Journal: (JOURNAL) of February/28,/2019
• what: The authors show that phosphorylation of tyrosine 344 (Y344) occurs and is required for 3u03b2HSD1 cellular activity and generation of u03944 3-keto-substrates of 5u03b1-reductase and aromatase including in patient tissues. The authors show that targeting BMX is a potential treatment strategy for CRPC.
• how: Collectively these results indicated that Y344 phosphorylation was essential . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or E-mail:

  If you don't have an account, you can create one here.