HIGHLIGHTS
SUMMARY
The following keywords were used to search the titles and abstracts in all databases: bone, osteoblasts, stem_cells, brain, nervous, diseases, molecule delivery in_vitro experiments and in_vivo experiments, with the Boolean operators (AND/OR/NOT). The bone is a dynamic tissue that consists mainly of skeletal cells and bone marrow (BM) and has various roles, such as mineral metabolism and the generation of immune cells, hematopoietic stem_cells and mesenchymal stem_cells. It has been reported that non-hematopoietic stem_cells present in BM not only provide support to the microenvironment of hematopoietic stem_cells, but also, thanks to . . .
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